However, L‐NAME (100 μM) completely reversed L‐arginine's effect.ĪZ and SNP reduced the AHF and IOP dose‐dependently. L‐NAME (L‐nitro‐L‐arginine) (10–100 μM), an NO synthase inhibitor, had no effect on AHF and IOP. L‐Arginine (1.0 mM), a precursor of NO, but not D‐arginine (1.0 mM), the inactive analogue, produced a significant reduction in AHF (28.5%) and IOP (21.1%). Perfusion pressure of the ocular vasculature was also monitored using digital pressure transducer and pen recorder. Using the porcine arterially perfused eye preparation, drug effects on AHF and IOP were measured by fluorescein dilution and manometry, respectively. The effect of nitric oxide (NO) on aqueous humour formation (AHF) and intraocular pressure (IOP) was studied using NO donors, sodium azide (AZ) and sodium nitroprusside (SNP). Shahidullah, Mohammad Yap, Maurice To, Chi‐ho Cyclic GMP, sodium nitroprusside and sodium azide reduce aqueous humour formation in the isolated arterially perfused pig eye Cyclic GMP, sodium nitroprusside and sodium azide reduce aqueous humour formation in the isolated.
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